Table 2.
ToppFun enrichment results
| Dispersion | Burden | |||||
|---|---|---|---|---|---|---|
| Category | Name | p-value | Bonferroni p-value | Name | p-value | Bonferroni p-value |
| Cellular component (GO) | Synapse | 6.36E−11 | 6.00E−08 | Synapse | 6.52E−23 | 9.13E−20 |
| Neuron part | 3.12E−09 | 2.95E−06 | Neuron part | 4.81E−20 | 6.73E−17 | |
| Neuron projection | 1.27E−08 | 1.20E−05 | Neuron projection | 1.75E−19 | 2.45E−16 | |
| Synapse part | 3.19E−08 | 3.01E−05 | Synapse part | 1.68E−18 | 2.36E−15 | |
| Cell projection part | 5.47E−08 | 5.16E−05 | Cell projection part | 2.21E−17 | 3.09E−14 | |
| Human disease (DisGeNETa) | Substance-related disorders | 4.50E−13 | 4.05E−09 | Substance-related disorders | 4.48E−13 | 7.18E−09 |
| Autism spectrum disorders | 2.37E−09 | 2.13E−05 | Autistic disorder | 2.85E−12 | 4.56E−08 | |
| Neuroblastoma | 4.92E−08 | 4.42E−04 | Schizophrenia | 3.95E−12 | 6.33E−08 | |
| Central neuroblastoma | 7.81E−08 | 7.02E−04 | Autism spectrum disorders | 1.61E−11 | 2.59E−07 | |
| Autistic disorder | 1.86E−07 | 1.67E−03 | Autosomal recessive predisposition | 4.11E−10 | 6.58E−06 | |
aDisGeNET: The DisGeNET database integrates human gene-disease associations from various databases for a large number of Mendelian and complex diseases