Fig. 6.

P2X7R antagonist A-438079 reduced BmK I-induced pain. A Pain behavior was attenuated after A-438079 pretreatment at 50 μmol/L, 100 μmol/L, and 300 μmol/L, 30 min before BmK I administration. B Reduction in the total number of paw flinches after A-438079 pretreatment at the above doses in the 2 h after BmK I injection. C–F A-438079 reduced the ipsilateral (C) and contralateral (D) mechanical hypersensitivity as well as the ipsilateral thermal hypersensitivity (E). A-438079 did not affect the contralateral basal thermal latency (F). n = 6/group; *P < 0.05, **P < 0.01, ***P < 0.001 compared with saline control group, one-way ANOVA, Dunnett’s post hoc test and two-way ANOVA, Bonferroni’s post hoc test.