Table 4.
Estimated AUC value of multi-marker panels for correlation with the presence of T2DM.
| Panels of significantly changed metabolites | AUC for correlation with T2DM |
|---|---|
| Comparison | T2DM vs. Control |
| Panels selected from CSF metabolites | AUC for CSF metabolites |
| Alanine, Histidine, Mannose | 0.985 |
| Alanine, Histidine, Mannose, Pyruvate | 0.992 |
| Alanine, Glycine, Histidine, Mannose, Pyruvate | 0.999 # |
| CSF glucose | 0.817 |
| Panels selected from plasma metabolites | AUC for plasma metabolites |
| Citrate, Histidine, N-acetyl-glycoprotein | 0.895 |
| Acetate, Citrate, Histidine, N-acetyl-glycoprotein | 0.907 |
| Acetate, Citrate, Histidine, Leucine, N-acetyl-glycoprotein | 0.907 # |
| Plasma glucose | 0.896 |
| Plasma HbA1c | 0.731 |
| Plasma HOMA-IR | 0.750 |
Abbreviation: T2DM, type 2 diabetes mellitus; AUC, area under the curve estimations; HbA1c, glycated hemoglobin A1c; HOMA-IR, Homeostatic Model Assessment for Insulin Resistance. # The panel with the highest AUC among the compared category.