Figure 2.

Proteomics Analysis of Downregulated Proteins Highlights BH₄/NO Modulation of Mitochondria and Metabolism

(A) GO term enrichment analysis of significantly downregulated proteins in Gch^fl/flTie2cre BMDMs stimulated with LPS/IFNγ. The most significant term in each cluster is annotated.

(B) Heatmap showing the scaled abundance of proteins identified in the mostly significantly enriched GO terms from the analysis of downregulated proteins (n = 4).

(C) mtDNA content was determined in Gch^fl/flTie2cre and iNOS KO cells (n = 4).