Table 3.
Subgroup analyses of risk factors for tumor recurrence after liver transplantation in 18 patients without hepatitis B virus infection and 20 patients with intrahepatic tumor dissemination.
| Factors | HBV-Negative (n = 18) |
Intrahepatic Dissemination (n = 20) |
||
|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | |
| Male sex | 0.65 (0.06–6.42) | 0.709 | 0.75 (0.15–3.84) | 0.735 |
| Age | 1.06 (0.88–1.28) | 0.516 | 1.01 (0.92–1.11) | 0.813 |
| MELD | 1.11 (0.98–1.25) | 0.098 | 1.02 (0.93–1.13) | 0.621 |
| HBV infection | - | - | 2.85 (0.75–10.79) | 0.123 |
| HCV infection | 1.04 (0.12–9.31) | 0.975 | 1.09 (0.22–5.41) | 0.918 |
| ALD | 1.88 (0.37–9.50) | 0.444 | 0.65 (0.13–3.19) | 0.598 |
| AFP model | 1.48 (1.01–2.17) | 0.004 | 1.43 (1.06–1.92) | 0.019 |
| Tumor number | 1.08 (0.83–1.41) | 0.558 | - | - |
| Tumor size | 1.04 (0.56–1.91) | 0.902 | 1.53 (1.01–2.30) | 0.044 |
| Alpha-fetoprotein | 1.13 (0.86–1.49) | 0.367 | 1.12 (0.91–1.38) | 0.269 |
| Ca 19-9 | 0.71 (0.13–4.01) | 0.700 | 0.91 (0.37–2.20) | 0.829 |
| Poor tumor differentiation | 1.83 (0.18–18.75) | 0.612 | 3.19 (0.72–14.10) | 0.127 |
| Microvascular invasion | 0.46 (0.07–3.09) | 0.425 | 0.78 (0.21–2.95) | 0.712 |
| Macrovascular invasion | 1.14 (0.16–8.11) | 0.896 | 2.21 (0.53–9.31) | 0.278 |
| Neoadjuvant treatment | 0.41 (0.05–3.61) | 0.421 | 1.11 (0.28–4.43) | 0.880 |
| Total ischemic time | 2.53 (1.19–5.37) | 0.016 | 1.83 (1.12–2.98) | 0.016 |
| Donor age | 0.90 (0.82–0.98) | 0.017 | 0.94 (0.89–0.99) | 0.041 |
| Male donor sex | 1.09 (0.22–5.42) | 0.915 | 0.76 (0.22–2.67) | 0.668 |
| Intraoperative PRBC transfusions (units) | 1.17 (0.94–1.47) | 0.162 | 1.09 (0.91–1.30) | 0.358 |
| Intraoperative FFP transfusions (units) | 1.07 (0.86–1.34) | 0.548 | 1.05 (0.88–1.24) | 0.619 |
Hazard ratios are for quantitative variables were given per: 1 year increase for recipient and donor age; 1 point increase for MELD; 1 increase for tumor number; 1 cm increase for tumor size; 1 loge increase for alpha-fetoprotein and Ca 19-9; 1 h increase for total ischemic time; 1 unit increase for transfusions. HR = hazard ratio; 95% CI = 95% confidence interval; MELD = model for end-stage liver disease; HBV = hepatitis B virus; HCV = hepatitis C virus; ALD = alcoholic liver disease; PRBC = packed red blood cells; FFP = fresh frozen plasma.