Table 3.
The application of animal models in mucormycosis research 1.
| Purpose | Host Species | Fungus | Route of Infection | References |
|---|---|---|---|---|
| Pathogenesis, virulence traits, comparative virulence | Mouse | Rhizopus spp. | pulmonary | [38,39,48,53,74] |
| i.v. | [74,75,76,77] | |||
| Mucor spp. | i.v. | [61,72,73,93,99,107,108] | ||
| Lichtheimia spp. | pulmonary | [35] | ||
| Rabbit | Rhizopus spp. | pulmonary | [62] | |
| Mucor spp. | pulmonary | [62] | ||
| Cunninghamella spp. | pulmonary | [62] | ||
| Lichtheimia spp. | pulmonary | [65,66] | ||
| Therapy and vaccines | Mouse | Rhizopus spp. | pulmonary | [39,41,42,43,44,45,46,47,49,51,52,54,56,57,58,59,60] |
| i.v. | [36,71,75,94,95,97,101,102,103,104,105] | |||
| cutaneous | [83] | |||
| Mucor spp. | i.v. | [43,96,97] | ||
| Rhizomucor spp. | i.v. | [97] | ||
| Lichtheimia spp. | i.v. | [94,97,113] | ||
| Cunninghamella spp. | i.v. | [97,98] | ||
| Diagnostics | Mouse | Rhizopus spp. | pulmonary | [40,50] |
| i.v. | [114] | |||
| Mucor spp. | pulmonary | [40] | ||
| i.v. | [114] | |||
| Rhizomucor spp. | i.v. | [114] | ||
| Lichtheimia spp. | pulmonary | [40] | ||
| i.v. | [114] | |||
| Cunninghamella spp. | pulmonary | [40] | ||
| Rabbit | Rhizopus spp. | pulmonary | [37] | |
| Mucor spp. | pulmonary | [37] | ||
| Lichtheimia spp. | pulmonary | [37] | ||
| Cunninghamella spp. | pulmonary | [37] |
1 Only studies published after 2000 and available online were included. A comprehensive list of studies using mammalian species published before 2000 is presented in Reference [26].