Table 2.
The function and related miRNAs of candidate differentially expressed genes (DEGs).
| Candidate DEGs | Regulation Direction of mRNA (HBFT/LBFT) | Gene Function | Related miRNAs |
|---|---|---|---|
| GLIPR1 | up | Protein coding gene, related to regulation of lipid metabolism by peroxisome proliferator-activated receptor alpha (PPARalpha) pathways | mir-13-3p, mir-31-5p, mir-215-5p, mir-3477-5p, mir-200-3p, mir-2-3p, mir-2188-5p |
| AQP9 | up | Encode aquaglyceroporins; facilitate the uptake of glycerol in hepatic tissue | mir-283-5p, mir-31-5p, mir-378-5p, mir-466-5p, mir-71-5p, mir-485-5p, mir-491-5p, mir-215-5p, mir-13-3p, mir-745-3p, mir-995-3p, mir-128-3p, mir-1388-3p, mir-196-5p, mir-3477-5p |
| SH2B1 | up | Encoded protein; mediate activation of various kinases; related to obsity | mir-276-3p, mir-6679-5p |
| GLYCTK | up | Encoded enzyme; catalyzes the phosphorylation of (R)-glycerate; associated with glycerolipid metabolism | mir-276-3p, mir-485-5p |
| DKK3 | up | Protein coding gene; related to Wnt/β-actin signaling | mir-184-3p, mir-28-5p, mir-3477-5p, mir-378-5p, mir-491-5p |
| NT5E | up | Encode a plasma membrane protein; associated with backfat thickness by SNP association analysis | mir-210, mir-3477-5p |
| DUSP2 | up | Encode phosphatase; associated with MAPK signaling pathway | mir-184-3p, mir-317-3p, mir-874-5p, ssc-miR-145-5p |
| CEP19 | down | Protein coding gene; linked to morbid obesity | novel-m0104-5p, novel-m0112-5p, novel-m0151-5p |
| TYSND1 | down | Encode protease; related to lipid metabolic; regulate fatty acid β-oxidation | lin-4-5p, mir-140-5p, mir-1692-5p, mir-1895-3p, mir-301-3p, mir-4787-5p, mir-3610-3p, mir-4497-5p, mir-6518-3p, mir-4286, novel-m0065-3p |