Table 2.
Univariate analysis of the correlation between GDF11 and other variables, unadjusted and after adjusting for age.
| Serum logGDF11 | ||||
|---|---|---|---|---|
| Unadjusted Correlation | Adjusted Correlation | |||
| Variable | r | p Value | r | p Value |
| Sex | −0.01 | 0.986 | −0.04 | 0.995 |
| Age | −0.16 | 0.006 | — | — |
| Weight | 0.14 | 0.018 | 0.10 | 0.084 |
| BMI | 0.15 | 0.009 | 0.14 | 0.021 |
| Body fat | 0.11 | 0.076 | 0.11 | 0.058 |
| FFM | 0.08 | 0.206 | 0.03 | 0.594 |
| FFMI | 0.10 | 0.094 | 0.08 | 0.212 |
| Waist circumference | 0.13 | 0.029 | 0.13 | 0.031 |
| SBP | 0.05 | 0.402 | 0.10 | 0.116 |
| DBP | 0.07 | 0.279 | 0.07 | 0.221 |
| REE | 0.10 | 0.149 | 0.05 | 0.509 |
| REE/FFM | 0.02 | 0.725 | −0.01 | 0.887 |
| Glucose | 0.01 | 0.969 | 0.04 | 0.544 |
| Insulin | 0.07 | 0.278 | 0.06 | 0.304 |
| HOMA | 0.06 | 0.308 | 0.06 | 0.295 |
| Triglycerides | 0.03 | 0.629 | 0.04 | 0.487 |
| Total cholesterol | 0.05 | 0.407 | 0.06 | 0.298 |
| LDL-cholesterol | 0.07 | 0.265 | 0.07 | 0.239 |
| HDL-cholesterol | −0.05 | 0.367 | −0.04 | 0.505 |
| Uric acid | 0.04 | 0.498 | 0.03 | 0.571 |
| logCRP | 0.19 | 0.025 | 0.18 | 0.038 |
| Creatinine | 0.06 | 0.310 | 0.09 | 0.146 |
| Leptin | 0.14 | 0.027 | 0.14 | 0.026 |
| logTSH | 0.40 | <0.001 | 0.38 | <0.001 |
Values are Pearson’s correlation coefficients and associated p values. CRP and TSH concentrations were logarithmically transformed for statistical analysis. GDF11: Growth differentiation factor 11; BMI: Body mass index; FFM: Fat-free mass; FFMI: Fat-free mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; REE: Resting energy expenditure; HOMA: Homeostatic model assessment; CRP: C-reactive protein; TSH: Thyroid-stimulating hormone; LDL: Low-density lipoprotein; HDL: High-density lipoprotein. For correlation with gender, male = 1 and female = 2 was used. Bold values denote statistical significance at p < 0.05.