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View full-text article in PMC

. 2019 Jun 21;8(6):893. doi: 10.3390/jcm8060893

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Plot of heatmap on the basis of computed IC50 values of the drugs eribulin, doxorubicin, and docetaxel for PMC42-LA and the four selected clones. (B) Measurements of central tendency from distribution of chromosome number across PMC42 LA, EpCAM sorted subpopulations and four clones. Student t-test was applied to calculate p-value. (C) Metaphase spreads of PMC42-LA chromosomes stained with DAPI and imaged with confocal microscopy. (D) Visualization of Control-FREEC v6.0 output from PMC42-LA sorted EpCAM subpopulations whole exome sequencing data (Illumina HiSeq 2000). Copy number profiles for all chromosomes are shown for EpCAM^low subpopulation in comparison to EpCAM^high; normal copy number status is shown in green, copy number gains are represented in red, and copy number losses are represented in blue.