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. 2019 Jun 13;8(6):846. doi: 10.3390/jcm8060846

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Correlation of serum acid sphingomyelinase (S-ASM) activity at inclusion with health-related quality of life assessed by the SF-12. High S-ASM levels were associated with a low physical component score in healthy individuals (a) and unmedicated patients with a current major depressive episode (b). High S-ASM levels were associated with a high mental component score in unmedicated and medicated male patients with a major depressive episode (c). Individual data with linear regression line and 95% confidence intervals.