Table 4.
Psychophysiological interactions of the bilateral VS in the desire context (DC) and during the desire-reason dilemma (DRD) (a, b), and of the bilateral VTA and hippocampus in the DC (c, d).
|
a) Influence of adversity during reward acceptance in the desire context (DC): Increased negative functional coupling between VS-VTA and VS-avPFC in the high adversity group | ||||
|---|---|---|---|---|
| Brain region | Seed area: R VS (12 4–4) |
Seed area: L VS (−14 10–2) |
||
| highA-lowR < lowA-lowR | highA-lowR > lowA-lowR | highA-lowR < lowA-lowR | highA-lowR > lowA-lowR | |
| MNI coordinates (t-value) | ||||
| L VTA | −12 −14 −16 (2.41)+ | n.s. | −4 −10 −10 (3.25) | n.s. |
| R avPFC | 14 52 16 (2.82) | n.s. | 8 66 18 (2.41)+ | n.s. |
| L avPFC | −18 50 10 (3.32) | n.s. | n.s. | n.s. |
| b) Influence of adversity during reward rejection in the ‘desire-reason dilemma’ (DRD): Impaired top-down control expressed by reduced negative VS-avPFC-coupling in the high adversity group | ||||
| Seed area: R VS (12 4–4) | Seed area: L VS (−14 10–2) | |||
| highA-lowR < lowA-lowR | highA-lowR > lowA-lowR | highA-lowR < lowA-lowR | highA-lowR > lowA-lowR | |
| R OFC | n.s. | 38 40–10 (3.45)⁎ | n.s. | 42 44–8 (3.28)⁎ |
| R avPFC | n.s. | 16 52 16 (3.13) | n.s. | 18 54 12 (2.93) |
| L avPFC | n.s. | −18 54 10 (3.09) | n.s. | −22 64 14 (4.23) |
| c) Influence of adversity and resilience during reward acceptance in the desire context (DC): Less negative VTA- VS -coupling in the high adversity and high resilient group | ||||
| Seed area: R VTA (8–26 –14) | Seed area: L VTA (−10–20 −8) | |||
| highA-highR < highA-lowR | highA-highR > highA-lowR | highA-highR < highA-lowR | highA-highR > highA-lowR | |
| L VS | n.s. | −12 16 2 (2.39)+ | n.s. | −16 4–6 (2.31)+ |
| d) Influence of adversity and resilience during reward acceptance in the desire context (DC): Less negative hippocampus-VS-coupling and hippocampus-VTA-coupling in the high adversity and high resilient group | ||||
| Seed area: R HP (36–18 −14) | Seed area: L HP (−36–22 –12) | |||
| highA-highR < highA-lowR | highA-highR > highA-lowR | highA-highR < highA-lowR | highA-highR > highA-lowR | |
| L VS | n.s. | −14 6–4 (2.26)+ | n.s. | n.s. |
| R VTA | n.s. | 4–16 –16 (3.00)⁎⁎ | n.s. | n.s. |
| L VTA | n.s. | n.s. | n.s. | −8 −16 −14 (2.73) |
Abbreviations: avPFC, anteroventral prefrontal cortex; highA, high adversity; highR, high resilience; L, left; HP, hippocampus; lowA, low adversity; lowR, low resilience; n.s., not significant; OFC, orbitofrontal cortex; R, right; VS, ventral striatum; VTA, ventral tegmental area.
Activations are reported at p < .005, uncorrected, with a minimum cluster size of 10 voxels; +p < .05, uncorrected, with a minimum cluster size of 10 voxels; ⁎p < .05, FWE-corrected (whole brain); ⁎⁎p < .017 FWE-corrected for small volume and adjusted for multiple parallel testing.