Table 2.
Associations of endodontic findings with saliva and serum antibody levels and bacterial concentrations.
| Root Canal Fillings | Widened Periapical Space | Apical Periodontitis | ||||
|---|---|---|---|---|---|---|
| Beta, p-Value | OR (95% CI), p | Beta, p-Value | OR (95% CI), p | Beta, p-Value | OR (95% CI), p | |
| Saliva IgA against bacteria * | 0.096, 0.041 | 2.162 (0.934–5.004), 0.072 | 0.062, 0.204 | 2.090 (1.007–4.337), 0.048 | 0.059, 0.235 | 1.995 (0.870–4.573), 0.103 |
| Saliva IgG against bacteria * | 0.169, <0.001 | 2.519 (1.431–4.434), 0.001 | 0.138, 0.005 | 2.246 (1.397–3.611), 0.001 | 0.182, <0.001 | 2.904 (1.714–4.922), <0.001 |
| Serum IgA against bacteria * | 0.031, 0.527 | 1.144 (0.516–2.539), 0.741 | 0.017, 0.738 | 1.513 (0.753–3.040), 0.245 | 0.037, 0.476 | 0.922 (0.421–2.018), 0.838 |
| Serum IgG against bacteria * | 0.010, 0.838 | 1.272 (0.443–3.656), 0.655 | 0.002, 0.963 | 2.048 (0.840–4.995), 0.115 | 0.083, 0.102 | 1.710 (0.615–4.754), 0.304 |
| Saliva pathogen sum | 0.012, 0.802 | 0.996 (0.932–1.064), 0.900 | 0.068, 0.163 | 1.046 (0.989–1.107), 0.117 | 0.079, 0.111 | 0.998 (0.936–1.064), 0.951 |
| Subgingival pathogen sum | 0.053, 0.273 | 0.991 (0.934–1.051), 0.760 | 0.086, 0.085 | 1.051 (0.999–1.105), 0.056 | 0.098, 0.049 | 1.047 (0.987–1.112), 0.127 |
| 45 gram-positive taxa | 0.025, 0.603 | 0.754 (0.515–1.104), 0.147 | 0.121, 0.014 | 1.395 (1.016–1.917), 0.040 | 0.045, 0.375 | 1.096 (0.761–1.578), 0.622 |
| 33 gram-negative taxa | 0.056, 0.237 | 0.945 (0.660–1.353), 0.757 | 0.121, 0.014 | 1.446 (1.046–1.999), 0.026 | 0.059, 0.238 | 1.249 (0.850–1.836), 0.257 |
| Saliva cross-reactive IgA ** | 0.086, 0.067 | 1.248 (0.926–1.680), 0.146 | 0.096, 0.049 | 1.295 (0.995–1.685), 0.055 | 0.064, 0.196 | 1.327 (0.986–1.788), 0.062 |
| Saliva cross-reactive IgG ** | 0.128, 0.006 | 1.240 (0.942–1.632), 0.125 | 0.160, 0.001 | 1.555 (1.217–1.987), <0.001 | 0.159, 0.001 | 1.615 (1.237–2.108), <0.001 |
The dependent variable in the linear regression was the number of findings and in the logistic regression the presence of findings. Adjusted for age, sex, marginal periodontitis (healthy, gingivitis, periodontitis), number of teeth, and smoking (never/ever). * Antibodies against A. actinomycetemcomitans, P. gingivalis, P. intermedia, P. endodontalis, and T. forsythia; ** Cross-reactive antibodies, antigens Pg-Rgp44, Aa-HSP60, and MAA-LDL.