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. 2019 Jun 21;8(6):189. doi: 10.3390/antiox8060189

Figure 2.

Figure 2

Treatment of mouse macrophage cell line, Raw 264.7, with apple pomace extracts, followed by incubation with lipopolysaccharide (LPS) from Escherichia coli as in vitro model of inflammation. (a) Cell viability (% of the control) of Raw 264.7 cells after incubation with polyphenolic-rich hot water extract (pHWE) at 0–1490 μg/mL in phosphate buffer/dimethyl sulfoxide (DMSO) (99.9:0.01; v/v). (b) Inhibitory effect of pHWE on LPS-induced nitrite production (% of the control) in Raw 264.7 cells. Data represent mean ± standard deviation of 3 independent assays. Different letters indicate statistical significance between pHWE concentrations (a,b,c, and d, p < 0.001) compared to control by one-way ANOVA followed by Tukey’s Multiple comparison test.