Table 2.

Some vasoactive substances capable of modulating vascular tone in different endothelial tissues.

Vasoactive Substance	Model	Tissue	Actions in Endothelium	References
Norepinephrine (NE)	Control group: Cyclic rats Experimental group: Ovariectomized rats (OVX)	Aorta (vascular smooth muscle) Treated in isometric myography system	-The vascular synthesis of both PGE2 and PGF2a was significantly higher in the group of OVX rats compared to the proestrous. -The vascular response to NE was significantly higher in OVX rats, compared to normal cycling rats during proestrous.	[205]
Cirazoline (α1-Adrenergic agonist)	Pregnant, proestrous and diestrous rats	Mesenteric vascular bed Treated by perfusion	-The tone induced by cirazoline was lower in the proestrous and pregnant groups, but the increase in the tone of L-NA is higher in pregnant compared to proestrous and diestrous group. The participation of EDRF in this effect is suggested.	[206]
Methacholine (Muscarinic agonist, endothelium-dependent vasodilator)	Control group: Experimental group: Pregnant mice	Uterine and mesenteric arteries Treated in isometric myography system	-The relaxation induced by methacholine was higher in pregnant mice, in both uterine artery and mesenteric vessels, with a more pronounced effect on the uterine vasculature. -Modulation of relaxation is endothelium-dependent PGHS or NOS pathways is reinforced in the uterine arteries.	[207]
Aspilia africana (Ethanolic extract)	Cyclic rats	Uterine endothelium Treatment by using an oropharyngeal cannula and calibrated hypodermic syringe	-Dose-dependent decrease in duration of estrous cycle and histoarchitecture of the uterus.	[208]
Buddleja globosa (Ethanolic extract)	Cyclic rats Ovariectomized rats (OVX)	Uterine endothelium Treatment administered subcutaneously with hypodermic syringe	Anti-estrogenic effect of extract of Buddleja globosa at the highest dose evaluated.	[209]