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. 2019 Jun 25;8(6):906. doi: 10.3390/jcm8060906

Figure 4.

Figure 4

(A) Retinal cryosections (20 µm) labeled with anti-cone arrestin to identify cone photoreceptors and counterstained with DAPI (blue) to label nuclei. Photoreceptor fragments exterior to the outer segments also label positively for cone-arrestin (boxes). Scale bar = 50 µm; Graphs depict the number of (B) cone arrestin positive cells and (C) DAPI-positive nuclei per 100 µm of the ONL. XBP1 cKO mice have significantly fewer cone photoreceptors and DAPI labeled nuclei; (D) Graph depicts the number of cone arrestin labeled fragments exterior to the outer segments for each group. There is a significant increase in cone arrestin positive fragments in DM mice, with a greater increase in XBP1 cKO DM mice. n = 3 for all groups; Mean ± S.D.; * p < 0.05.