Table 3.
Pregnancy and live birth outcomes of frozen-thawed embryos in the two groups.
| Outcomes | Late stimulation protocol group | Short GnRH-a protocol group | P-value |
|---|---|---|---|
| No. of patients, n | 64 | 53 | |
| No. of FET cycles, n | 75 | 80 | |
| No. of transferred embryos, mean (SD) | 1.87 (0.342) | 1.80 (0.403) | 0.268 |
| Endometrium preparation, n | 0.409 | ||
| Natural cycle | 44 | 47 | |
| Stimulated cycle | 26 | 23 | |
| Hormone replacement therapy | 5 | 10 | |
| PREGNANCY OUTCOME OF FET | |||
| Biochemical pregnancy rate per transfer, % (no. of FET cycles with positive serum hCG results /no. of all the FET cycles) | 64.00 (48/75) | 55.00 (44/80) | 0.254 |
| Clinical pregnancy rate per transfer, % (no. of intrauterine and ectopic pregnancy cycles with or without fetal heart activity /no. of all the FET cycles) | 61.33 (46/75) | 52.50 (42/80) | 0.267 |
| Multiple pregnancy rate, % (no. of FET cycles with more than one gestational sac/no. of all the clinical pregnancy cycles) | 26.09 (12/46) | 21.43 (9/42) | 0.609 |
| Implantation rate, % (no. of gestation sac /no. of embryos transferred) | 40.71 (57/140) | 34.72 (50/144) | 0.297 |
| Ectopic pregnancy rate, % (no. of FET cycles with ectopic pregnancy /no. of all the clinical pregnancy cycles) | 2.170 (1/46) | 2.38 (1/42) | 0.962 |
| Early miscarriage rate % (no. of FET cycles with empty gestational sac or stopped fetal heart before the gestational age of 12 weeks / no. of all the clinical pregnancy cycles) | 6.52 (3/46) | 14.29 (6/42) | 0.300 |
| LIVE-BIRTH OUTCOMES | |||
| Live birth cycle, n | 11 | 25 | 0.699 |
| Term delivery | 9 | 19 | |
| Preterm delivery | 2 | 6 | |
| New-born | 0.869 | ||
| Single birth, n | 9 | 20 | |
| Twin birth, n | 4 | 10 | |
| Single birth weight (g), mean (SD) | 3532.22 (478.82) | 3157.50 (669.41) | 0.199 |
| Twin birth weight (g), mean (SD) | 2250.00 (227.30) | 2480.00 (356.06) | 0.374 |
FET, frozen embryo transfer; GnRH-a, Gonadotropin-releasing hormone agonist.