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. 2019 Jul 9;9:9900. doi: 10.1038/s41598-019-46044-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Study design. A 4-week baseline period was followed by 12-week treatment period. A total of 96 subjects completed all 12 weeks of treatment; however, 6 subjects did not fill out the electronic headache diary, and 7 did not meet the inclusion criteria regarding the number of migraine attacks in the baseline period. These 13 subjects were therefore excluded, leaving 83 ultimately included in the analyses.