Table 1.

Agents that induce RPB1 poly-ubiquitylation and degradation, and the range of doses used in the literature (recommended dose in brackets).

Reagent	Dose (Human)	Dose (yeast)
UVC-irradiation	2–100 J/m2 (typically 5–20 J/m2)	Up to 300 J/m2
Cisplatin	5–50 μM for 1 h	Not used
4-NQO	0.2–5 μM for 1 h	50 μM, 30 min
6-AU	Not tested	2 mM, 2–3 h
Alpha amanitin	2–50 μM (10 μM) for 4 h	Not used