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. 2019 Jul 3;9:604. doi: 10.3389/fonc.2019.00604

Table 1.

The Clavien-Dindo classification system for medical and surgical complications.

Grade Description Number of patients (%)
Grade 1 Any deviation from the normal post-operative course not requiring surgical, endoscopic, or radiological intervention. Allowed therapeutic regimens are: drugs as anti-emetics, antipyretics, analgesics, diuretics, electrolytes, and physiotherapy. This grade also includes wound infections opened at the bedside 39 (46.4)
Grade 2 Requiring pharmacological treatment with drugs other than such allowed for Grade I complications. Blood transfusions and total parenteral nutrition are also included 12 (14.2)
Grade 3 Complications requiring surgical, endoscopic, or radiological intervention. They are distinguished into: Grade 3a—intervention not under general anesthetic Grade 3b—intervention under general anesthetic 24 (28.5)
Grade 4 Life-threatening complications. This includes central nervous system complications which require intensive care. They are distinguished into: Grade 4a–single-organ dysfunction (including dialysis) Grade 4b–multi-organ dysfunction 5 (5.9)
Grade 5 Death 4 (4.7)