Table 6.
Baseline SF-36/RAND-36 quality of life scores (0–100) for patients with CLI
| Publication | Instrument | PF | RP | BP | GH | VT | SF | RE | MH | PCS | MCS | CLI Population | Procedure(s) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Burt (2010)38 | SF-36 | – | – | – | – | – | – | – | – | 31.1 | 57.6 | 100% | Autologous peripheral blood cell implantation |
| Deutschmann (2007)39 | SF-36 | 24.8 | 5.6 | 13.9 | 50a | 28.1 | 70a | 28.5 | 46a | – | – | 52% | Percutaneous transluminal angioplasty |
| Engelhardtb (2008)40 | SF-36 | 25 | 12 | 21 | 56 | 41 | 50 | 38 | 56 | 100% | Infrageniculate bypass surgery | ||
| Forbes (2010)41 | SF-36 SF-36 |
22.7 23.0 |
10.3 13.1 |
30.4 32.0 |
49.1 48.0 |
34.2 36.3 |
40.6 44.2 |
31.5 36.3 |
58.9 60.1 |
100%c 100%c |
Angioplasty Bypass surgery |
||
| Keeling (2008)42 | SF-36 | 35.6 | 16.7 | 39.3 | 60.4 | 44.4 | 71.8 | 55.6 | 75.5 | – | – | 44% | Percutaneous transluminal angioplasty |
| Kumar (2011)43 | RAND-36 | 20.9 | 21.1 | 31.7 | 28.9 | 21.8 | 28.6 | 23.5 | – | – | – | 100% | Various revascularization procedures |
| Landry (2014)44 | SF-36 | 30 | 4 | 25 | 49 | 42 | 47 | 57 | 69 | – | – | 100% | Lower extremity bypass surgery |
| Peeters Weemd (2016)45 | SF-36 | 33 | 38 | 45 | 38 | 48 | 41 | 45 | 47 | 35 | 49 | 100%d | Autologous bone marrow cell therapy |
| Shigematsu (2010)46 | SF-36 | 24.4 22.9 |
28.7 2.1 |
32.1 30.1 |
38.4 36.8 |
43.1 45.0 |
50.5 45.8 |
30.9 11.1 |
50.6 59.0 |
100% | Hepatocyte growth factor plasmid No treatment |
||
| Sprengers (2010)14 | SF-36 | 28 | 34.4 | 32.9 | 39.7 | 44.8 | 36.9 | 39.5 | 42.6 | 30.8 | 45.9 | 100% | Bone marrow cell therapy |
| van Hattume (2011)47 | RAND-36 | 49 | 38 | 59 | 55 | 55 | 65 | 56 | 68 | 37 | 48 | 28% | Bypass surgery |
| Wohlgemuth (2008)48 | SF-36 | 40.7 | 26.9 | 17.6 | 29.3 | 55.6 | 70.2 | 51.9 | 62.3 | 70% | Bypass surgery | ||
| Maglinte (2012)49 | SF-36 | 50.7 | 49.5 | 50.6 | 50.1 | 53.7 | 51.4 | 51.4 | 54.3 | 49.2 | 53.8 | - | US population norms |
Notes: aBaseline SF-36 scores estimated from figure #3 in Deutschmann 2007;39 bA weighted average of the baseline SF-36 scores for the three patient subgroups (Non-Diabetes, Diabetes, and Secondary Amputation) from Table #3 in Engelhardt 2008;40 cCLI population defined as “severe lower limb ischemia” in the Forbes 201041 study (BASIL trial); dFor the purpose of this analysis, the CLI patient population from the Peeters Weem 201645 study was defined as patients with “no option severe limb ischemia”; baseline SF-36 scores estimated from figure #2 in Peeters Weem 2016;45 eFor the purposes of this analysis, the SF-36 scores presented in the table earlier are from Table II in the van Hattum 201147 study for the Bypass and Oral Anticoagulants or Aspirin (BOA) Study group.
Abbreviations: BP, Bodily Pain; CLI, critical limb ischemia; GH, General Health; MCS, Mental Component Summary; MH, Mental Health; PCS, Physical Component Summary; PF, Physical Functioning; RAND-36, 36-item Short-Form Health Survey; RE, Role Emotional; RP, Role Physical; SF, Social Functioning; SF-36, 36-item Short-Form Health Survey; VT, Vitality.