Table 2.

Cox regression analysis of survival for ever smokers among NSCLC patients

Variables	OS		PFS
	HR (95% CI)	P value	HR (95% CI)	P value
Univariate analysis
Age (years)
< 60	1		1
≥ 60	1.29 (0.64–2.58)	0.468	1.25 (0.66–2.34)	0.488
Gender
Female	1		1
Male	1.26 (0.30–5.30)	0.746	1.22 (0.36–4.08)	0.747
Performance status
0	1		1
1–2	1.76 (0.76–4.04)	0.18	1.41 (0.70–2.80)	0.331
cStage
III	1		1
IV	1.35 (0.66–2.75)	0.404	1.84 (0.96–3.53)	0.066
Histology
Non-AD	1		1
AD	1.37 (0.70–2.66)	0.352	1.71 (0.93–3.15)	0.183
Tumor differentiation
Well/moderate	1		1
Poor	1.58 (0.80–3.12)	0.187	1.14 (0.61–2.14)	0.677
Naive CD4+
Low	1		1
High	0.35 (0.17–0.70)	0.001	0.60 (0.32–1.12)	0.09
Memory CD4+
Low	1		1
High	1.51 (0.76–2.98)	0.223	1.36 (0.73–2.51)	0.298
Naive CD8+
Low	1		1
High	0.72 (0.36–1.41)	0.335	0.54 (0.29–1.01)	0.037
Memory CD8+
Low	1		1
High	1.24 (0.63–2.44)	0.519	1.50 (0.81–2.77)	0.175
CD4+ naive/memory
Low	1		1
High	0.48 (0.24–0.97)	0.03	0.78 (0.42–1.44)	0.411
CD8+ naive/memory
Low	1		1
High	0.69 (0.35–1.36)	0.279	0.53 (0.28–0.99)	0.032
Naive CD8/CD4
Low	1		1
High	1.26 (0.64–2.47)	0.491	0.89 (0.48–1.63)	0.708
Memory CD8/CD4
Low	1		1
High	1.35 (0.68–2.64)	0.377	1.56 (0.84–2.87)	0.133
Multivariate analysis
Naive CD4+
Low	1		1
High	0.11 (0.02–0.55)	0.007	0.73 (0.35–1.52)	0.400
CD4+ naive/memory
Low	1		–
High	3.63 (0.77–16.95)	0.101	–	–
Naive CD8+
Low	–		1
High	–	–	0.69 (0.11–4.17)	0.693
CD8+ naive/memory
Low	–		1
High	–	–	0.80 (0.12–5.03)	0.815
cStage
III	–		1
IV	–	–	1.97 (0.99–3.92)	0.051