Table 3.

Cox regression analysis of survival for never smokers among NSCLC patients

Variables	OS		PFS
	HR (95% CI)	P value	HR (95% CI)	P value
Univariate analysis
Age (years)
< 60	1		1
≥ 60	0.46 (0.19–1.09)	0.081	0.44 (0.21–0.95)	0.036
Gender
Female	1		1
Male	1.81 (0.76–4.32)	0.18	2.06 (0.94–4.52)	0.07
Performance status
0	1		1
1–2	1.36 (0.39–4.70)	0.625	1.32 (0.50–3.50)	0.568
cStage
III	1		1
IV	0.98 (0.36–1.70)	0.981	0.73 (0.32–1.65)	0.451
Histology
Non-AD	1		1
AD	0.87 (0.35–3.15)	0.77	0.81 (0.36–1.79)	0.61
Tumor differentiation
Well/moderate	1		1
Poor	1.86 (0.76–4.50)	0.169	2.74 (1.22–6.14)	0.014
Naive CD4+
Low	1		1
High	3.19 (1.38–7.40)	0.009	2.07 (0.97–4.41)	0.062
Memory CD4+
Low	1		1
High	0.92 (0.40–2.13)	0.855	0.75 (0.35–1.61)	0.47
Naive CD8+
Low	1		1
High	1.61 (0.69–3.72)	0.273	1.70 (0.79–3.62)	0.165
Memory CD8+
Low	1		1
High	0.76 (0.33–1.77)	0.536	0.77 (0.36–1.65)	0.509
CD4+ naive/memory
Low	1		1
High	1.77 (0.76–4.08)	0.187	2.07 (0.97–4.42)	0.056
CD8+ naive/memory
Low	1		1
High	1.29 (0.56–2.99)	0.544	1.33 (0.62–2.83)	0.455
Naive CD8/CD4
Low	1		1
High	1.16 (0.50–2.70)	0.706	0.98 (0.46–2.09)	0.964
Memory CD8/CD4
Low	1		1
High	0.72 (0.31–1.68)	0.451	0.62 (0.29–1.33)	0.214
Multivariate analysis
Naive CD4+
Low	1		1
High	2.17 (1.15–5.49)	0.012	2.43 (0.22–26.80)	0.468
CD4+ naive/memory
Low	–
High	–	–	0.82 (0.09–7.18)	0.858
Age (years)
< 60	1		1
≥ 60	0.47 (0.19–1.13)	0.094	0.70 (0.28–1.74)	0.447
Gender
Female	–		1
Male	–	–	1.79 (0.72–4.48)	0.209
Tumor differentiation
Well/moderate	–		1
Poor	–	–	2.07 (0.84–5.08)	0.112