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. 2019 Jul 9;11:100. doi: 10.1186/s13148-019-0695-0

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Discovery set unsupervised hierarchical clustering analysis based on the average methylation β value for the two aberrantly methylated CGIs. Heatmap obtained by UHC of 50 BTC samples and 10 matched normal samples. The UHC analysis clearly separated one group of sole tumours and another group including normal and tumoral samples. To the right of the heatmap further information are reported: histology, localization and grade. BTC, biliary tract cancer