Table 2.
Ventilator settings, arterial blood gases averaged on day 1 to 3 and other therapies
| Ventilator settings | Recovery (96) | Non-recovery (148) | p value |
|---|---|---|---|
| Spontaneous tidal volume, median (IQR), mL | 474 (417–539) | 499 (428–555) | 0.13 |
| Tidal volume, median (IQR), (mL/kg PBW) | 7.3 (6.6–8) | 7.6 (6.9–8.6) | 0.01* |
| PEEP, median (IQR), cm H2O | 10 (8–13) | 11 (8.4–14) | 0.08 |
| FiO2, median (IQR) | 0.7 (0.53–0.82) | 0.7 (0.58–0.9) | 0.24 |
| Plateau pressure, median (IQR), cm H2O | 26.5 (21.3–34.4) | 27.5 (23–33) | 0.45 |
| Plateau pressure > 30 cm H2O, n (%) | 22 (37.9) | 29 (35.4) | 0.76 |
| Driving pressure, median (IQR), cm H2O | 15.0 (11.5–19) | 14.5 (12–19) | 0.85 |
| Mean airway pressure, median (IQR), cm H2O | 17.7 (14.5–21.8) | 18 (14.8–21.2) | 0.82 |
| Peak airway pressure, mean (SD), cm H2O | 31 (6.9) | 31.3 (7.6) | 0.82 |
| Minute ventilation, median (IQR), L/min | 11 (9.2–12.9) | 11.6 (9.9–13.5) | 0.20 |
| Arterial blood gas | |||
| Arterial pH, median (IQR) | 7.36 (7.3–7.41) | 7.35 (7.29–7.39) | 0.06 |
| PaCO2, median (IQR), mm Hg | 43.7 (38–51.2) | 41.3 (34.8–48) | 0.07 |
| PaO2, median (IQR), mm Hg | 87.7 (74.8–112) | 87.3 (76–109.2) | 0.93 |
| PaO2:FiO2, median (IQR) | 138 (111–178) | 138 (95–195) | 0.94 |
| Oxygenation index, median (IQR) | 15.6 (9.2–23.5) | 13.9 (9.1–24.4) | 0.89 |
| Rescue therapies, n (%) | |||
| Continuous neuromuscular blocking agents | 27 (28.1) | 72 (48.6) | 0.001* |
| Inhaled vasodilators | 18 (18.8) | 46 (31.1) | 0.03* |
| Prone positioning | 14 (14.6) | 20 (13.5) | 0.81 |
| Extracorporeal membrane oxygenation | 3 (3.1) | 4 (2.7) | 1.00 |
| Recruitment maneuvers | 3 (3.1) | 17 (11.5) | 0.02* |
| High frequency oscillatory ventilation | 2 (2.1) | 9 (6.1) | 0.21 |
| Other therapies | |||
| Sedative drugs, n (%) | 77 (80.2) | 117 (79.1) | 0.83 |
| Analgesic drugs, n (%) | 70 (72.9) | 106 (71.6) | 0.83 |
| Antipsychotic drugs, n (%) | 48 (50) | 56 (37.8) | 0.06 |
| Furosemide on day 2–7, n (%) | 63 (65.6) | 71 (48) | 0.01* |
| Fluid overload on day 7, mean (SD), % | 5.5 (8.2) | 10 (8.7) | 0.003* |
FiO2 = fraction of inspired oxygen, IQR = interquartile range, PaCO2 = partial pressure of carbon dioxide in arterial blood, PaO2 = partial pressure of oxygen in arterial blood, PBW = predicted body weight, PEEP = positive end-expiratory pressure, SD = standard deviation
*p < 0.05 when compared with patients complete renal recovery