Table 1.
Author, year | Title | Sample | Study design | Assessments | Main findings |
---|---|---|---|---|---|
Munkholm et al. (2018) | Leukocytes in peripheral blood from patients with BD-trait and state alterations and association with levels of cytokines and C-reactive protein | n = 169 (97 BD patients and 72 HC) | Prospective cohort | IL-6, IL-8, IL-18, TNF-α, hsCRP, together with leukocytes and neutrophils in blood |
Leukocyte and neutrophil counts both higher in patients with BD than HCs. Serum IL-6, TNF-α, and hsCRP levels positively associated with leukocyte and neutrophil counts Plasma level of IL-6 increased in patients with BD and MD |
Wu et al. (2017) | Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study | n = 65 (23 BD patients, 22 MD patients, and 20 HCs) | Prospective cohort | T lymphocyte subsets and IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ in blood |