Fig. 3.

Ablation of Bcl6b amplified inflammation upon BaP treatment. (a) qRT-PCR revealed TNF-α, IL-1β and IL-8 mRNA levels in Bap-induced gastric tumours (27 week) from Bcl6b^−/− mice and WT controls. (b) ELISA revealed serum protein levels of TNF-α and IL-1β in WT and Bcl6b^−/− mice after intragastric administration of BaP (27 week). (c) Representative images and quantification of CD3-immunopositive cells in Bap-induced gastric tumours (27 week) from Bcl6b^−/− mice and WT controls. Scale bar, 50 μm. Data are presented as the mean ± SD; n = 5 per group. *P < 0.05; **P < 0.01; ***P < 0.001; unpaired two-tailed Student’s t tests