Fig. 6.

BCL6B was associated with inflammation and survival in GC patients and mice. (a-c) Negative correlations between BCL6B and TNF-α (a), IL-1β (B) and IL-8 (c) mRNA levels in human gastric cancer tissues were measured using Pearson’s correlation test (r and P values are shown in the graphs, n = 45). (d) Representative immunostaining of BCL6B and CD3 in human gastric cancer tissue microarrays. Scale bar, 100 μm (top) and 20 μm (bottom). Kaplan-Meier survival curves from overall gastric cancer patients based on BCL6B protein expression and BCL6B-negative gastric cancer patients based on CD3 protein expression. Survival analysis was performed using a log-rank test. (e) Kaplan-Meier survival curves of WT and Bcl6b^−/− mice after intragastric administration of BaP to induce gastric cancer with or without 5-Aza treatment. Survival analysis was performed using a log-rank test. *P < 0.05; **P < 0.01; ***P < 0.001; NS, not significant