Skip to main content
. 2019 Feb 13;145(4):962–973. doi: 10.1002/ijc.32176

Figure 1.

Figure 1

BRCA data. (a) Clinical classification of Chinese BRCA data as pathogenic, likely pathogenic, uncertain significance, likely benign, benign and unclassified. The pathogenic and likely pathogenic variants accounted for 49.5%. (b) Relationship between population sizes and their contribution to current BRCA data. The proportions of different human ethnic populations were from the database (http://www.worldometers.info/world‐population/), the ethnic origins of BRCA data were from different BRCA databases. It shows that the current BRCA data is not proportional to the human ethnic populations. (c) Comparison of BRCA data between Chinese and non‐Chinese populations. A total of 557 BRCA1 and 531 BRCA2 Chinese variants were compared to 6,344 BRCA1 and 8,886 BRCA2 non‐Chinese variants compiled from all existing BRCA databases. The results show that 38% of Chinese BRCA variants were present only in the Chinese population.