Table 3.

Comparison of Clinical classification between Chinese and BIC BRCA variants

	BRCA1					BRCA2
Class	Chinese	Proportion	BIC	Proportion	p value	Chinese	Proportion	BIC	Proportion	p value
Pathogenic	233	0.418	729	0.417	0.248	247	0.465	753	0.378	0.000
Likely pathogenic	25	0.045	‐			35	0.066	‐	‐	‐
Uncertain signi.	71	0.127	10	0.006	0.000	44	0.083	4	0.002	0.000
Likely benign	25	0.045	‐	‐	‐	15	0.028	‐	‐	‐
Benign	37	0.066	23	0.013	0.000	31	0.058	49	0.025	0.001
Unclassified	166	0.298	988	0.565	0.000	159	0.299	1,188	0.596	0.000
Total	557		1,750			531		1,994