Table 2.
Patient characteristics according to time until recurrence
|
Recurrence within 6 months (n = 55) |
All other patients (n = 267) |
P ‡ | |
|---|---|---|---|
| Age (years) * | 64(10) | 66(10) | 0·150§ |
| Sex ratio (M : F) | 29: 26 | 132: 135 | 0·657 |
| Death | 53 (96) | 178 (66·7) | < 0·001 |
| Survival (months) † | 8 | 23 | < 0·001¶ |
| Tumour size (mm) * | 32(14) | 28(16) | 0·083§ |
| Adjuvant therapy | 23 (42) | 149 (55·8) | 0·058 |
| Tumour differentiation | 0·078 | ||
| Well | 6 (11) | 57 (21·3) | |
| Moderate | 20 (36) | 113 (42·3) | |
| Poor | 29 (53) | 95 (35·6) | |
| Undifferentiated | 0 (0) | 2 (0·7) | |
| Lymph node‐positive | 43 (78) | 179 (67·0) | 0·104 |
| No. of positive lymph nodes ‡ | 2 (0–4) | 2 (1–5) | 0·125# |
| Tumour stage | 0·192 | ||
| IA | 2 (4) | 25 (9·4) | |
| IB | 1 (2) | 10 (3·7) | |
| IIA | 9 (16) | 50 (18·7) | |
| IIB | 38 (69) | 169 (63·3) | |
| III | 3 (5) | 12 (4·5) | |
| IV | 2 (4) | 1 (0·4) | |
| Perineural invasion | 40 (73) | 161 (60·3) | 0·083 |
| Lymphangioinvasion | 15 (27) | 55 (20·6) | 0·275 |
| Resection margin | 0·071 | ||
| R0 | 27 (49) | 166 (62·2) | |
| R1 | 28 (51) | 101 (37·8) |
Values in parentheses are percentages unless indicated otherwise; values are
*
mean(s.d.),
†
median (95 per cent c.i.) and ‡median (i.q.r.). R0, resection margin free from tumour cells; R1, tumour cells within 1 mm of resection margin.
‡
χ2 test, except
§
Student's t test,
¶
log rank test and
#
Mann–Whitney U test.