Table 1.
Basic characteristics of discussed studies
| Study | Subjects | Daily Dosage | Duration of Treatment |
|---|---|---|---|
| Myo‐inositol | |||
| Corrado et al13 | 84, diet treated women with GDM | Myo 4 g plus folic acid 400 μg | 8 weeks |
| D'Anna et al14 | 220, pregnant women with a parent with type 2 diabetes at 12‐13 weeks of gestation | Myo 4 g plus folic acid 400 μg | From first trimester to delivery |
| D'Anna et al15 | 220, pregnant obese women | Myo 4 g plus folic acid 400 μg | From first trimester to delivery |
| Santamaria et al16 | 220, pregnant overweight women | Myo 4 g plus folic acid 400 μg | From first trimester to delivery |
| Matarrelli et al17 | 75, non‐obese singleton pregnant women with an elevated fasting glucose in the first or early second trimester | Myo 4 g plus folic acid 400 μg | From first trimester to delivery |
| d‐chiro‐inositol | |||
| Di Biase et al18 | 137, women with GDM | DCI 1 g | From first trimester to delivery |
| Comparison between Myo‐inositol, d‐chiro‐inositol, and Myo‐inositol plus d‐chiroinositol formulations | |||
| Malvasi et al19 | 65, healthy pregnant women between the 13th and 24th week of gestation | Myo 2 g, DCI 400 mg, folic acid 400 μg, plus manganese 10 mg | 8 weeks |
| Fraticelli et al20 | 80, GDM women | Myo 4 g plus folic acid 400 μg DCI 500 mg plus folic acid 400 μg Myo/DCI 1,1 g/27,6 mg plus folic acid 400 μg folic acid 400 μg (control treatment | 8 weeks |
| Dell'Edera et al21 | 83 women | 250 mg/day d‐chiro‐inositol, 1.75 g/day d‐myo‐inositol, 12.5 mg/day zinc, 10 mg/day methylsulfonylmethane, 400 μg/day 5‐methyltetrahydrofolic acid 400 μg/day folic acid (control group) | From first trimester to delivery |
| Farren et al22 | 240, women between 10 and 16 weeks ‘gestation | Myo/DCI 1.1/27.6 mg, folic acid 400 μg | From first trimester to delivery |
| Celentano et al23 | 157 pregnant women with fasting glucose≥92 mg/dl and ≤ 126 mg/dl at first trimester blood exams | Myo 4 g plus folic acid 400 μg DCI 500 mg plus folic acid 400 μg Myo/DCI 1,1 g/27,6 mg plus folic acid 400 μg folic acid 400 μg (control treatment | From first trimester to delivery |
| Comparison between Myo‐imnositol plus d‐chiro‐inositol and Myo‐inositol plus d‐chiro‐inositol plus Revifast formulation | |||
| Malvasi et al24 | 104, pregnant women | Revifast 80 mg plus Myo/DCI 200 mg/500 mg Myo 138 mg/DCI 500 mg placebo | From 24th and 28th weeks' gestation for 60 days |
| Epigallocatechin 3‐gallate | |||
| Zhang et al25 | 472 GDM women during third trimester | EGCG 500 mg | From third trimester to delivery |
Abbreviations: DCI, d‐chiro inositol; EGCG, epigallocatechin 3‐gallate; GDM, gestational diabetes; Myo, myoinositol.