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. 2019 Jan 4;94(3):1023–1037. doi: 10.1111/brv.12487

Figure 4.

BRV-12487-FIG-0004-c

Sub‐compartmentalization of the LIN‐17/Frizzled receptor in Caenorhabditis elegans. In the DA9 motor neurons, a posterior gradient of the LIN‐44/Wnt ligand (green) and a ventral gradient of EGL‐20/Wnt (purple) define the axonal sub‐compartmentalization of LIN‐17/Frizzled receptors, which in turn confines the localization of presynaptic RAB‐3 molecules (gold circles) to the distal segment of the DA9 motor neuron axon (orange). EGL, egg‐laying defective; LIN, abnormal cell lineage; Wnt, wingless.