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. 2019 Apr 23;125(14):2409–2422. doi: 10.1002/cncr.32053

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© 2019 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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p63 is a critical downstream effector of microRNA 130b (miR‐130b). (A) The relative proliferation of HEYA8 and OVCAR8 cells after overexpression of the transactivation (TA) domain of tumor protein p63 (TAp63). Error bars indicate the standard deviation of 3 biologic replicates. Asterisks indicate P < .01. NT indicates no treatment; vector, pCDNA3.1 empty vector. (B) Oncoprints generated from the cBioPortal Cancer Genomics (available at: http://www.cbioportal.org/, Accessed March 3, 2019) indicate that p63 is altered in 146 patients who had 603 samples (25%). (C) This is a Kaplan‐Meier survival curve of miR‐130b, TAp63, and the N‐terminally truncated (ΔN) isoform of p63 (ΔNp63) from The Cancer Genome Atlas. HR indicates hazard ratio.