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. 2019 Apr 23;125(14):2409–2422. doi: 10.1002/cncr.32053

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© 2019 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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In vivo chemosensitization of ovarian tumors by 1,2‐dioleoyl‐sn‐glycero‐3‐phosphatidylcholine (DOPC)–microRNA 130b (miR‐130b) is illustrated in an orthotopic mouse model of ovarian cancer. Athymic nude mice bearing OVCAR8 xenograft tumors were treated with DOPC–miR‐130b and/or cisplatin (CDDP) (miR‐130b + CDDP) twice weekly for 5 weeks. Normal control (NC) mice treated with DOPC–miR were used as controls. (A) In these images (from week 3), green corresponds to the highest signal intensity (and, thus, to tumor burden), and blue corresponds to the lowest signal intensity. Bar charts illustrate (B) the quantification of luminescence signal intensities and (C) Kaplan‐Meier curves for the chemosensitization study.