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Quantitative systems pharmacology (QSP) model integrated features and development workflow (a) QSP models. (b) QSP model development workflow. NLME, nonlinear mixed‐effects; PK, pharmacokinetics; SBML, systems biology markup language. SAS, Statistical Analysis System; FIM, Fisher Information Matrix; PPC, PPC, Posterior Predictive Checks; VPC, Visual Predictive Check; NLFE, Nonlinear Fixed Effect.
