Table 3.
Antibiotic resistance patterns of Gram-negative bacteria producing ESBLs and AmpC β-lactamases compared to nonproducer isolates.
| Antibiotic | Total number of Gram-negative rods (n = 311) | p value | Total number of Gram-negative rods (n = 311) | p value | ||
|---|---|---|---|---|---|---|
| Non-ESBL (n = 227) | ESBL (n = 84) | AmpC (n = 101) | Non-AmpC (n = 210) | |||
| Amikacin | 31 (36.9) | 61(26.9) | 0.085 | 57 (56.4) | 35 (16.7) | <0.001 |
| Tobramycin | 50 (42) | 92 (40.5) | 0.134 | 67 (66.3) | 67 (31.9) | <0.001 |
| Gentamicin | 40 (47.6) | 81 (35.7) | 0.055 | 66 (65.3) | 55 (26.2) | <0.001 |
| Amoxicillin/clavulanate | 58 (69) | 91 (40.1) | <0.001 | 93 (92.1) | 56 (26.7) | <0.001 |
| Cefuroxime | 81 (96.4) | 137 (60.4) | <0.001 | 92 (91.1) | 126 (60) | <0.001 |
| Ceftazidime | 72 (85.7) | 76 (33.5) | <0.001 | 65 (64.4) | 83 (39.5) | <0.001 |
| Cefotaxime | 78 (92.9) | 85 (37.4) | <0.001 | 76 (75.2) | 87 (41.4) | <0.001 |
| Cefepime | 75 (89.3) | 87 (38.3) | <0.001 | 75 (74.3) | 87 (41.4) | <0.001 |
| Meropenem | 24 (28.6) | 59 (26.0) | 0.755 | 50 (49.5) | 33 (15.7) | <0.001 |
| Piperacillin | 53 (63.1) | 77 (33.9) | <0.001 | 72 (71.3) | 58 (27.6) | <0.001 |
| Piperacillin/tazobactam | 42 (50) | 77 (33.9) | 0.010 | 65 (64.4) | 54 (25.7) | <0.001 |
| Imipenem | 26 (31) | 62 (27.3) | 0.527 | 58 (57.4) | 30 (14.3) | <0.001 |
| Aztreonam | 69 (82.1) | 98 (43.2) | <0.001 | 82 (81.2) | 85 (40.5) | <0.001 |
| Ciprofloxacin | 51 (60.7) | 92 (40.5) | 0.002 | 74 (73.3) | 69 (32.9) | <0.001 |
| Ofloxacin | 50 (59.5) | 91 (40.1) | 0.002 | 70 (69.3) | 71 (33.8) | <0.001 |
| Nitrofurantoin | 50 (59.5) | 103 (45.4) | 0.027 | 78 (77.2) | 75 (35.7) | <0.001 |
| Trimethoprim/sulfamethoxazole | 76 (90.5) | 140 (61.7) | <0.001 | 91 (90.1) | 125 (59.5) | <0.001 |
| Colistin | 4 (4.8) | 5 (2.2) | 0232 | 7 (6.9) | 2(1.0) | 0.003 |