Fig. 3.

OA stimulation of the PPARα pathway: (A) Schematic representation of the PPARα/PGC-1α axis: PPARα binds to RXR, the heterodimer is activated by ligands and PGC-1α acts as a co-activator for PPARα. The heterotrimer binds to the PPARα response element (PPRE), in the promoter of target genes. (B) The effect of 75 μM, 150 μM or 300 μM of OA on cell viability after 1 week of incubation. (C) Effect of 48 h supplementation with OA at increased concentrations. Effect of OA 75 μM, 150 μM, 300 μM on the expression of PPARα, PGC-1α in P4 CPCs, normalised to OA 75 μM. (n = 4, *p < .02, #p < .01, indicating difference to OA 75 μΜ; error bars: standard error).