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. 2019 Mar 26;286(12):2295–2310. doi: 10.1111/febs.14812

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© 2019 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Amino acid sequence alignments of Hydra magnipillata (hy) Tcf with the Homo sapiens (h) and Gallus gallus (ck) homologs. (A) Alignment with human TCF4 (TCF7L2) and chicken Tcf4 (Tcf7l2). (B) Alignment with human LEF‐1 and chicken Lef1. GenBank accession numbers are: hy Tcf, NP_001296662; h TCF‐4, CAG38811; ck Tcf‐4, NP_001193439; h LEF‐1, Q9UJU2; ck Lef‐1, NP990344. Identical residues are shaded in blue, and gaps are indicated by dashes. The β‐Catenin (CTNNB) and DNA binding (HMG) domains are boxed in pink or yellow, respectively. Sequence identities between hy Tcf and h LEF1 or ck Lef1 are 29%, and between hy Tcf and h TCF4 or ck Tcf4 42%. The alignment was generated by using the computer program (omega) clustalw with additional manual adjustments.