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Hydra β‐Catenin/Myc interaction model. Interstitial stem cells permanently undergo self‐renewal and differentiation into three somatic products: nerve cells, stinging cells (nematocytes), and gland cells. We propose that Myc2 acts as maintenance factor in interstitial stem cell self‐renewal and that this is complemented by a double‐negative action of β‐Catenin and Myc1. The detailed actions of β‐Catenin on Myc2 and the cross‐talk between Myc1 and Myc2 are not yet known.
