Table 4.
Sensitivity, specificity, positive and negative predictive values of cognitive measures
| Test (cut‐off) | Sensitivity (%) | Specificity (%) | Positive predictive value (%) | Negative predictive value (%) |
|---|---|---|---|---|
| Semantic dementia versus other groups | ||||
| Manchester word picture comprehension test (<40/40) | 62.5 | 92.3 | 62.5 | 92.3 |
| Proportion action to object naming (>1.1) | 87.5 | 86.8 | 58.3 | 97.1 |
| Narrative: percent nouns (<11.5) | 75.0 | 84.6 | 50.0 | 94.3 |
| Narrative: proportion nouns to verbs (<0.4) | 62.5 | 89.7 | 55.6 | 92.1 |
| Behaviour: social behaviour (>5/9) | 75.0 | 75.9 | 30.0 | 95.7 |
| Behaviour: response to environment (>1/3) | 25.0 | 93.1 | 33.3 | 90.0 |
| Behaviour: hobbies, order and routines (>2/8) | 75.0 | 72.4 | 27.3 | 95.5 |
| Calculation (>8/12) | 87.5 | 76.3 | 43.7 | 96.7 |
| Non‐fluent/agrammatic variant primary progressive aphasia versus other groups | ||||
| Manchester reading (<40/40) | 40.0 | 91.4 | 57.1 | 84.2 |
| Manchester sentence ordering: order (<4/10) | 66.7 | 87.9 | 66.7 | 87.9 |
| Manchester sentence ordering: reading (<10/10) | 91.7 | 78.1 | 61.1 | 96.2 |
| Manchester sentence ordering: to dictation (<6/10) | 66.7 | 96.9 | 88.9 | 88.9 |
| Narrative: phonemic errors per 100 words (>0.9) | 81.8 | 80.0 | 56.3 | 93.3 |
| Narrative: words per minute (<82.5) | 100.0 | 85.7 | 68.8 | 100.0 |
| Narrative: percentage well‐formed sentences (<35.7%) | 62.5 | 97.1 | 83.3 | 91.9 |
| Narrative: mean length of utterance (<7.2 words) | 81.8 | 82.9 | 60.0 | 93.5 |
| Narrative: number of dependent clauses per utterance (<0.12) | 100.0 | 62.9 | 40.9 | 100.0 |
| Narrative: number of fluency disruptions per 100 words (>28.4) | 63.6 | 88.6 | 63.6 | 88.6 |
| Orofacial praxis total (<24/25) | 100.0 | 77.1 | 60.0 | 100.0 |
| Orofacial praxis actions (<9/10) | 58.3 | 100.0 | 100.0 | 87.5 |
| Orofacial praxis sounds (<3/3) | 91.7 | 91.4 | 78.6 | 97.0 |
| Orofacial praxis emotions (<6/6) | 75.0 | 80.0 | 56.3 | 90.3 |
| Orofacial praxis pantomimes (<4/6) | 41.7 | 100.0 | 100.0 | 83.3 |
| Logopenic variant primary progressive aphasia versus other groups | ||||
| Manchester immediate and delayed word repetition (<35/36) | 76.9 | 52.9 | 38.5 | 85.7 |
| Manchester immediate and delayed word repetition: immediate (<17/18) | 38.4 | 76.5 | 38.5 | 76.5 |
| Manchester immediate and delayed word repetition: delayed (<18/18) | 76.9 | 38.2 | 32.3 | 81.3 |
| Sentence repetition (<22/24) | 46.2 | 69.7 | 37.5 | 76.7 |
| Digit span forwards (<7) | 100.0 | 14.7 | 31.0 | 100.0 |
| Digit span reverse (<5) | 100.0 | 5.9 | 28.9 | 100.0 |
| Visual patterns span (<6) | 84.6 | 34.4 | 34.4 | 84.6 |
| Visual array comparison test: location (<1) | 25.0 | 77.4 | 30.0 | 72.7 |
| Visual array comparison test: colour (<7) | 91.7 | 9.7 | 28.2 | 75.0 |
| Pointing span (<5) | 69.2 | 42.4 | 32.1 | 77.8 |
| Brown–Peterson: total (<47/54) | 100.0 | 50.0 | 39.3 | 100.0 |
| Brown–Peterson: immediate (<18/18) | 100.0 | 38.2 | 34.4 | 100.0 |
| Brown–Peterson: delayed (<9/18) | 54.5 | 79.4 | 46.2 | 84.4 |
| Brown–Peterson: distraction (<17/18) | 100.0 | 29.4 | 31.4 | 100.0 |
| Logopenic variant primary progressive aphasia versus semantic dementia and non‐fluent variant PPA | ||||
| Manchester immediate and delayed word repetition (<35/36) | 76.9 | 60.0 | 55.6 | 80.0 |
| Manchester immediate and delayed word repetition: immediate (<17/18) | 38.5 | 75.0 | 50.0 | 65.2 |
| Manchester immediate and delayed word repetition: delayed (<17/18) | 61.5 | 60.0 | 50.0 | 70.6 |
| Sentence repetition (<22/24) | 46.2 | 68.4 | 50.0 | 65.0 |
| Digit span forwards (<6) | 84.6 | 30.0 | 44.0 | 75.0 |
| Digit span reverse (<4) | 76.9 | 35.0 | 43.5 | 70.0 |
| Visual patterns span (<6) | 84.6 | 50.0 | 55.0 | 81.8 |
| Visual array comparison test: location (<1) | 25.0 | 88.2 | 60.0 | 62.5 |
| Visual array comparison test: colour (<7) | 91.7 | 17.6 | 44.0 | 75.0 |
| Pointing span (<5) | 69.2 | 52.6 | 50.0 | 71.4 |
| Brown–Peterson: total (<47/54) | 100.0 | 65.0 | 61.1 | 100.0 |
| Brown–Peterson: immediate (<18/18) | 100.0 | 45.0 | 50.0 | 100.0 |
| Brown–Peterson: delayed (<16/18) | 81.8 | 60.0 | 52.9 | 85.7 |
| Brown–Peterson: distraction (<17/18) | 100.0 | 40.0 | 47.8 | 100.0 |