Figure 4.
SW mice are resistant to P. aeruginosa 6294‐induced keratitis. (A) Cohorts of SW (N = 9) and C57BL/6 (N = 5) mice were infected with 1 × 106 CFU of P. aeruginosa 6294 and bacterial burdens in the cornea quantified at 48 h after the onset of infection. Student's t test. Experiments were repeated trice. (B) SW‐derived PMNs kill P. aeruginosa 6294 more efficiently than C57BL6/N‐derived PMNs. Mature neutrophils were purified from bone marrow of SW and C57BL/6N mice (stem cell), and exposed to 6294 at MOI 1 for 90 min as in Dwyer and Gadjeva, and Ray. Aliquots from the reactions were plated. Student's t test. Data are representative of two independent experiments