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. 2019 May 17;71(7):1078–1088. doi: 10.1002/art.40835

Figure 1.

Figure 1

Development of mechanical hypersensitivity after mechanical joint loading. The right knees of mice were loaded 3 times per week for 2 weeks at 9N (n = 8) (A and B) or 11N (n = 8) (C and D) to induce osteoarthritis. Development of mechanical hypersensitivity was measured using von Frey filaments (50% paw withdrawal threshold [PWT]) in the ipsilateral paws (A and C) and contralateral paws (B and D). Results were compared to those in nonloaded anesthetized controls (n = 8). Values are the mean ± SEM. # = P < 0.05; ## = P < 0.01; ### = P < 0.001, versus mechanical joint loading. * = P < 0.05; ** = P < 0.01; *** = P < 0.001, versus baseline. Color figure can be viewed in the online issue, which is available at http://onlinelibrary.wiley.com/doi/10.1002/art.40835/abstract.