Table 1.
Clinical characteristics of early arthritis patients.
| Early arthritis | Early RA | ||
|---|---|---|---|
| “Cohort A” | “Cohort B” | “Cohort C” | |
| Number of patients | 26 | 20 | 14 |
| Age; yearsa | 51 (20–82) | 66.5 (33–87) | 65 (21–89) |
| Female, n (%) | 15 (58) | 7 (70%) | 9 (64) |
| ESR, mm/seconda | 9 (2–84) | 26 (9–122) | 21 (9–122) |
| CRP, g/La | 5 (<5–65) | 26.5 (4–278) | 8.5 (4–150) |
| ACPA+, n (%) | 8 (31) | 55 | 57 |
| RF+, n (%) | 10 (39) | 55 | 57 |
| DAS28 (RA only)1 | 4.8 (1.33–8.46) | 5.12 (2.49–7.83) | 3.68 (2.12–6.29) |
| Diagnosis, n (%): | |||
| RA: | 10 (38%) | 20 (all) | 14 (all) |
| Inflammatory, non-RA: | 6 (24%) | – | – |
| OA/non-inflammatory: | 10 (38%) | – | – |
Distinct cohorts were recruited for measuring circulating CD4+ T-cell parameters in distinct experiments as indicated in the text. Surface IL-6R and gp130 expression was measured in Cohort A, CD25 expression in Cohort B and intracellular interferon-γ and IL-17 expression following in vitro stimulation in Cohort C.
a
Median and range are presented; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; ACPA, anti-citrullinated peptide autoantibody; RF, rheumatoid factor; DAS28, disease activity score, 28 joints; RA, rheumatoid arthritis; OA, osteoarthritis.