Table 4.
Biomarker | Ontuxizumab at 8 mg/kg + G/D (n = 139) | Placebo + G/D (n = 70) |
---|---|---|
Endosialin lymphatic endothelial cell M score | 12.8 | 13.3 |
Endosialin membranous tumor cell M score | 4.2 | 4.3 |
Endosialin nonvascular stromal cell M score | 18.3 | 18.7 |
Endosialin perivascular cell M score | 24.1 | 22.9 |
Endosialin venous endothelial cell M score | 19.1 | 16.8 |
Log plasma endosialin, ng/mL | 11.463 | 11.486 |
PDGFR‐β arterial endothelial cell M score | 3.4 | 3.2 |
PDGFR‐β capillary endothelial cell M score | 30.0 | 29.0 |
PDGFR‐β cytoplasmic tumor cell M score | 22.7 | 21.5 |
PDGFR‐β lymphatic endothelial cell M score | 22.0 | 21.7 |
PDGFR‐β membranous tumor cell M score | 8.3 | 4.7 |
PDGFR‐β nonvascular stromal cell M score | 21.4 | 23.4 |
PDGFR‐β perivascular cell M score | 31.8 | 29.8 |
PDGFR‐β venous endothelial cell M score | 3.6 | 3.5 |
Log plasma PDGFR‐β, ng/mL | 7.830 | 7.872 |
Abbreviations: G/D, gemcitabine and docetaxel; PDGFR‐β, platelet‐derived growth factor receptor β.