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. 2019 Apr 29;70(1):259–275. doi: 10.1002/hep.30613

Figure 8.

Figure 8

miR‐148a directly binds and down‐regulates lnc‐UCID. (A) Ectopic expression of miR‐148a or antagonism of cellular miR‐148a affected lnc‐UCID expression. Forty‐eight hours after transfection with the indicated RNA oligoribonucleotides, HepG2 cells were analyzed by quantitative real‐time PCR. (B) miR‐148a suppressed Renilla luciferase activity of the reporters containing the wild‐type but not mutant lnc‐UCID. WT, psi‐UCID‐WT; MUT, psi‐UCID‐MUT. (C) miR‐148a expression was significantly decreased in HCC tissues. miR‐148a expression was analyzed in 27 paired HCC and adjacent nontumor liver tissues by quantitative real‐time PCR. (D) Expression of miR‐148a was negatively correlated with lnc‐UCID level. Statistical analysis was performed using Pearson's correlation coefficient. (E) Model of the miR‐148a/lnc‐UCID/DHX9/CDK6 axis and its role in cell proliferation and tumorigenesis. **P < 0.01; ***P < 0.001. Abbreviations: MUT, mutant; and WT, wild type.