Table 3.
Foetal and infant growth patterns and correlation with ocular biometry at 6 years of age (N = 3849)
| Axial length (mm) | Corneal radius (mm) | AL/CR ratio | |
|---|---|---|---|
| Foetal restricted | Beta (95% CI) | Beta (95% CI) | Beta (95% CI) |
| Infant restricted (n = 85) | −0.17 (−0.32 to −0.01) | −0.11 (−0.17 to −0.06) | 0.02 (0.00 to 0.04) |
| Infant normal (n = 424) | −0.19 (−0.27 to −0.11) | −0.07 (−0.10 to −0.04) | 0.00 (−0.01 to 0.01) |
| Infant accelerated (n = 490) | −0.13 (−0.21 to −0.06) | −0.07 (−0.10 to −0.04) | 0.01 (0.00 to 0.02) |
| Foetal normal | |||
| Infant restricted (n = 306) | −0.09 (−0.18 to 0.00) | −0.04 (−0.08 to −0.01) | 0.01 (−0.01 to 0.01) |
| Infant normal (n = 876) | Ref | Ref | Ref |
| Infant accelerated (n = 514) | 0.10 (0.03 to 0.18) | 0.03 (0.00 to 0.06) | 0.00 (−0.01 to 0.01) |
| Foetal accelerated | |||
| Infant restricted (n = 394) | 0.12 (0.04 to 0.20) | 0.03 (0.00 to 0.06) | 0.00 (−0.01 to 0.01) |
| Infant normal (n = 564) | 0.19 (0.12 to 0.27) | 0.07 (0.05 to 0.10) | −0.00 (−0.01 to 0.01) |
| Infant accelerated (n = 164) | 0.28 (0.17 to 0.39) | 0.11 (0.07 to 0.15) | −0.00 (−0.01 to 0.01) |
Values are regression coefficients and 95% confidence intervals for the beta for increase axial length (mm), corneal radius (mm) or AL/CR ratio from linear regression models. “n =“represents number of total group. p < 0.05 are shown in bold. Models were adjusted for gender, age at visit, ethnicity and SDS estimated foetal weight at second trimester. Restricted growth, normal growth and accelerated growth were defined as respectively <−0.67, >−0.67 and <0.67 and >0.67 standard deviation score (SDS) difference in SDS weight between second trimester and birth and birth and 6 months post‐natal. Bonferroni adjusted p‐values are shown in bold (p < 0.002).