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. 2019 Mar 19;34(6):1101–1114. doi: 10.1002/jbmr.3691

Figure 3.

Figure 3

Decreased bone strength and stiffness in Slc20a2–/– mice. (A) Representative load displacement curves from three‐point bend testing of humeri from P112 WT, Slc20a2+/–, and Slc20a2–/– female mice showing yield load, maximum load, fracture load, and the gradient of the linear elastic phase (stiffness). Graphs showing yield, maximum load, and fracture load, and stiffness (mean ± SE, n = 6, per genotype, **p < 0.01, ***p < 0.001 versus WT; ANOVA followed by Tukey's post hoc test). (B) μCT images of the proximal tibial metaphysis and mid‐diaphyseal tibial cortical bone from P112 WT, Slc20a2+/–, and Slc20a2–/– female mice. Scale bar = 1 mm. (C) Graphs showing BV/TV, Tb.N, Tb.Th, Ct.Diameter, Ct.Th, and cortical BMD (mean ± SE, n = 6 per genotype, *p < 0.05, ***p < 0.001, versus WT; ANOVA followed by Tukey's post hoc test). (D) Representative BSE‐SEM images of the distal femur from P112 WT, Slc20a2+/–, and Slc20a2–/– mice. Scale bars = 1 mm (n = 4 to 5 per sex, per genotype). BV/TV = trabecular bone volume per tissue volume; Tb.N = trabecular number; Tb.Th = trabecular thickness; Ct.Diameter = external cortical diameter; Ct.Th = cortical thickness.