Table 2.
The Association between the Cognitive Reserve Indicator and Dementia
| Reserve Indicator | Subjects, n | Cases, n | Basic Adjusted, HR (95% CI)a | p | Multiadjusted, HR (95% CI)b | p |
|---|---|---|---|---|---|---|
| Continuous | 2,556 | 232 | 0.76 (0.68–0.85) | <0.001 | 0.77 (0.69–0.86) | <0.001 |
| By tertile | ||||||
| Low | 816 | 133 | Reference | Reference | ||
| Moderate | 849 | 68 | 0.69 (0.51–0.93) | <0.001 | 0.68 (0.50–0.92) | 0.011 |
| High | 891 | 41 | 0.40 (0.27–0.60) | <0.001 | 0.42 (0.28–0.63) | <0.001 |
| p for trend | 0.65 (0.54–0.78) | <0.001 | 0.65 (0.54–0.79) | <0.001 | ||
Cox proportional hazard models. Separate Cox models estimated for continuous and categorical versions of reserve indicator.
a
Adjusted for age cohorts and sex.
b
Adjusted for age cohorts, sex, smoking, body mass index, heart disease, hypertension, cerebrovascular diseases, diabetes, and APOE‐ε4.
CI = confidence interval; HR = hazard ratio.