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. Author manuscript; available in PMC: 2019 Jul 10.
Published in final edited form as: Biochemistry. 2019 Jun 25;58(27):2953–2966. doi: 10.1021/acs.biochem.9b00401

Figure 9.

Figure 9

Familial Alzheimer’s disease (FAD) hot spots in PSEN1. (A) Sixty-one residues that are each mutated to two or more different amino acids in FAD are colored purple. Only PSEN1 and the APP substrate are shown for the sake of clarity. Note that many of these mutation sites appear to face or interact with the substrate. (B) Mutation sites that interact with the helical region of the substrate. (C) Mutation sites that interact, directly or indirectly, with the substrate in the active site and with the substrate β-strand. Protein Data Bank entry 6IYC.