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. Author manuscript; available in PMC: 2020 Jun 10.
Published in final edited form as: J Control Release. 2019 Apr 4;303:289–301. doi: 10.1016/j.jconrel.2019.03.030

Figure 2:

Figure 2:

FUS-facilitated delivery. a. CT-based simulation revealed the FUS beam focus in situ (mouse skull is indicated in white). b. Passive cavitation detection was used to monitor the sonication in real-time without (orange) and with (blue) microbubbles. c. BBB opening was confirmed with contrast-enhanced T1-weighted MRI (left) and rendered in 3D (middle). No edema was observed on T2 MRI one-day post sonication.